An expedient method for resolution of 3-amino-3-(3′-pyridyl)propionic acid and related compounds

被引：9

作者：

Boesch, H

Cesco-Cancian, S

Hecker, LR

Hoekstra, WJ

Justus, M

Maryanoff, CA

Scott, L

Shah, RD

Solms, G

Sorgi, KL

Stefanick, SM

Thurnheer, U

Villani, FJ

Walker, DG

机构：

[1] Cilag AG, CH-8205 Schaffhausen, Switzerland

[2] RW Johnson Pharmaceut Res Inst, New Prod Res, Dept Chem Dev, Raritan, NJ 08869 USA

[3] RW Johnson Pharmaceut Res Inst, New Prod Res, Dept Chem Dev, Spring House, PA 19477 USA

[4] RW Johnson Pharmaceut Res Inst, Drug Discovery, Spring House, PA 19477 USA

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2001年 / 5卷 / 01期

关键词：

D O I：

10.1021/op990192m

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Preparation of methyl (S)-3-amino-3-(3'-pyridyl)propionate dihydrochloride in high enantiomeric purity by selective crystallization of a diastereomeric salt of a carboxylic add precursor (N-BOC-protected) with (1R,2S)-(-)-ephedrine is described. Further demonstration of the usefulness of this procedure to resolve other 3-amino-3-[(substituted)pyridyl]propionic acids is also described.

引用

页码：23 / 27

页数：5

共 21 条

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