Modulation of the Postischemic Immune Response to Improve Stroke Outcome

被引:29
作者
Becker, Kyra J. [1 ]
机构
[1] Univ Washington, Harborview Med Ctr, Sch Med, Seattle, WA 98104 USA
关键词
immunology; inflammation; neuroprotection; ACUTE ISCHEMIC-STROKE; NERVOUS-SYSTEM AUTOIMMUNITY; RAT CEREBRAL-CORTEX; BRAIN ANTIGENS; T-CELLS; MULTIPLE-SCLEROSIS; FOCAL ISCHEMIA; PROTEIN; TRIAL; EXPRESSION;
D O I
10.1161/STROKEAHA.110.592881
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Recent advances in understanding how the poststroke immune response may contribute to ischemic brain injury are discussed in this article. In particular, the potential of modulating the postischemic immune response to improve stroke outcome is explored. (Stroke. 2010;41[suppl 1]:S75-S78.)
引用
收藏
页码:S75 / S78
页数:4
相关论文
共 42 条
[1]   Pneumonia and urinary tract infection after acute ischaemic stroke: a tertiary analysis of the GAIN International trial [J].
Aslanyan, S ;
Weir, CJ ;
Diener, HC ;
Kaste, M ;
Lees, KR .
EUROPEAN JOURNAL OF NEUROLOGY, 2004, 11 (01) :49-53
[2]   Systemic inflammatory response depends on initial stroke severity but is attenuated by successful thrombolysis [J].
Audebert, HJ ;
Rott, MM ;
Eck, T ;
Haberl, RL .
STROKE, 2004, 35 (09) :2128-2133
[3]   INTERLEUKIN-6 AND INTERLEUKIN-1 RECEPTOR ANTAGONIST IN ACUTE STROKE [J].
BEAMER, NB ;
COULL, BM ;
CLARK, WM ;
HAZEL, JS ;
SILBERGER, JR .
ANNALS OF NEUROLOGY, 1995, 37 (06) :800-805
[4]   Adoptive transfer of myelin basic protein-tolerized splenocytes to naive animals reduces infarct size - A role for lymphocytes in ischemic brain injury? [J].
Becker, K ;
Kindrick, D ;
McCarron, R ;
Hallenbeck, J ;
Winn, R .
STROKE, 2003, 34 (07) :1809-1815
[5]   Sensitization to brain antigens after stroke is augmented by lipopolysaccharide [J].
Becker, KJ ;
Kindrick, DL ;
Lester, MP ;
Shea, C ;
Ye, ZC .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2005, 25 (12) :1634-1644
[6]   Antibodies to brain antigens following stroke [J].
Bornstein, NM ;
Aronovich, B ;
Korczyn, AD ;
Shavit, S ;
Michaelson, DM ;
Chapman, J .
NEUROLOGY, 2001, 56 (04) :529-530
[7]   Spatiotemporal relationship of apoptotic cell death to lymphomonocytic infiltration in photochemically induced focal ischemia of the rat cerebral cortex [J].
Braun, JS ;
Jander, S ;
Schroeter, M ;
Witte, OW ;
Stoll, G .
ACTA NEUROPATHOLOGICA, 1996, 92 (03) :255-263
[8]   Flow cytometric analysis of inflammatory cells in ischemic rat brain [J].
Campanella, M ;
Sciorati, C ;
Tarozzo, G ;
Beltramo, M .
STROKE, 2002, 33 (02) :586-592
[9]   The early systemic prophylaxis of infection after stroke study - A randomized clinical trial [J].
Chamorro, A ;
Horcajada, JP ;
Obach, V ;
Vargas, M ;
Revilla, M ;
Torres, F ;
Cervera, A ;
Planas, AM ;
Mensa, J .
STROKE, 2005, 36 (07) :1495-1500
[10]   Mucosal tolerance to E-selectin provides cell-mediated protection against ischemic brain injury [J].
Chen, Y ;
Ruetzler, C ;
Pandipati, S ;
Spatz, M ;
McCarron, RM ;
Becker, K ;
Hallenbeck, JM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (25) :15107-15112