Comparison of motivations and concerns for genetic testing in hereditary colorectal and breast cancer syndromes. Electronic letter

被引:47
作者
Esplen, M. J.
Madlensky, L.
Aronson, M.
Rothenmund, H.
Gallinger, S.
Butler, K.
Toner, B.
Wong, J.
Manno, M.
McLaughlln, J.
机构
[1] Univ Toronto, Fac Med, Dept Psychiat, Toronto, ON M5G 2C4, Canada
[2] Univ Hlth Network, Toronto Gen Res Inst, Hlth Res Div, Toronto, ON M5G 2C4, Canada
关键词
colorectal cancer; expectations; genetic testing; motivations; psychological adjustment; sex differences;
D O I
10.1111/j.1399-0004.2007.00893.x
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Hereditary non-polyposis colorectal cancer (HNPCC) represents about 1-3% of all cases of colorectal cancer (CRC). The objectives of the study were to examine motivational factors, expectations and psychosocial functioning in a sample of CRC survivors undergoing genetic testing for HNPCC. A cross-sectional survey of 314 colorectal cancer patients recruited through a population-based colon cancer family registry was conducted. Motivations for genetic testing for hereditary cancer were similar to those of clinic-based samples of CRC patients and included learning of the increased risk to offspring and finding out if additional screening was needed. While age at diagnosis and sex were associated with psychological functioning, significant predictors of post-counseling distress were perceived lower satisfaction with social support, an escape-avoidant coping style and the anticipation of becoming depressed if a mutation was present. Most cancer survivors anticipated disclosing test results to relatives and physicians. Cancer survivors reported several motivations for genetic testing for HNPCC that varied by sex. A subgroup of survivors with lower satisfaction with social support and an escape-avoidant coping style were worried about the potential impact of genetic test results and demonstrated more distress following counseling. Findings have implications for future research and potential support needs during the genetic counseling and testing process.
引用
收藏
页码:394 / 401
页数:8
相关论文
共 48 条
[1]   Psychological consequences of predictive genetic testing for hereditary non-polyposis colorectal cancer (HNPCC):: A prospective follow-up study [J].
Aktan-Collan, K ;
Haukkala, A ;
Mecklin, JP ;
Uutela, A ;
Kääriäinen, H .
INTERNATIONAL JOURNAL OF CANCER, 2001, 93 (04) :608-611
[2]   Comparison of motivations and concerns for genetic testing in hereditary colorectal and breast cancer syndromes -: art. no. e44 [J].
Balmaña, J ;
Stoffel, EM ;
Emmons, KM ;
Garber, JE ;
Syngal, S .
JOURNAL OF MEDICAL GENETICS, 2004, 41 (04)
[3]   Stress and genetic testing for disease risk [J].
Baum, A ;
Friedman, AL ;
Zakowski, SG .
HEALTH PSYCHOLOGY, 1997, 16 (01) :8-19
[4]  
Bonadona V, 2002, CANCER EPIDEM BIOMAR, V11, P97
[5]   Intention to participate in predictive genetic testing for hereditary cancer: The role of attitude toward uncertainty [J].
Braithwaite, D ;
Sutton, S ;
Steggles, N .
PSYCHOLOGY & HEALTH, 2002, 17 (06) :761-772
[6]   Motivations and concerns of women considering genetic testing for breast cancer: A comparison between affected and at-risk probands [J].
Brandt, R ;
Hartmann, E ;
Ali, Z ;
Tucci, R ;
Gilman, P .
GENETIC TESTING, 2002, 6 (03) :203-205
[7]   The hereditary nonpolyposis colorectal cancer syndrome: Genetics and clinical implications [J].
Chung, DC ;
Rustgi, AK .
ANNALS OF INTERNAL MEDICINE, 2003, 138 (07) :560-570
[8]   Health beliefs and endoscopic screening for colorectal cancer: Potential for cancer prevention [J].
Codori, AM ;
Petersen, GM ;
Miglioretti, DL ;
Boyd, P .
PREVENTIVE MEDICINE, 2001, 33 (02) :128-136
[9]  
Cotterchio M, 2000, Chronic Dis Can, V21, P81
[10]   Distress and psychiatric morbidity among women from high-risk breast and ovarian cancer families [J].
Coyne, JC ;
Benazon, NR ;
Gaba, CG ;
Calzone, K ;
Weber, BL .
JOURNAL OF CONSULTING AND CLINICAL PSYCHOLOGY, 2000, 68 (05) :864-874