Chimeric antigen receptor T cell therapy: 25 years in the making

被引：173

作者：

Gill, Saar ^{[1
]}

Maus, Marcela V. ^{[1
]}

Porter, David L. ^{[1
]}

机构：

[1] Univ Penn Hlth Syst, Div Hematol Oncol, Philadelphia, PA USA

来源：

BLOOD REVIEWS | 2016年 / 30卷 / 03期

关键词：

Chimeric antigen receptor T cells; Adoptive immunotherapy; ACUTE MYELOID-LEUKEMIA; CHRONIC LYMPHOCYTIC-LEUKEMIA; NON-HODGKIN-LYMPHOMA; PHASE-I; ADOPTIVE IMMUNOTHERAPY; GENE-THERAPY; ANTITUMOR-ACTIVITY; DOSE-ESCALATION; VIVO EXPANSION; CLINICAL-TRIAL;

D O I：

10.1016/j.blre.2015.10.003

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Chimeric antigen receptor (CAR) T cell therapy of cancer is generating enormous enthusiasm. Twenty-five years after the concept was first proposed, major advances in molecular biology, virology, and good manufacturing practices (GMP)-grade cell production have transformed antibody-T cell chimeras from a scientific curiosity to a fact of life for academic cellular immunotherapy researchers and, increasingly, for patients. In this review, we explain the preclinical concept, outline how it has been translated to the clinic, and draw lessons from the first years of CART cell therapy for the practicing clinician. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：157 / 167

页数：11

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