Influence of chlorhexidine species on the liquid crystalline structure of vehicle

被引：19

作者：

Farkas, E

Zelkó, R

Török, G

Rácz, I

Marton, S

机构：

[1] Semmelweis Univ, Inst Pharmaceut, H-1092 Budapest, Hungary

[2] Hungarian Acad Sci, Res Inst Solid State Phys, H-1121 Budapest, Hungary

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2001年 / 213卷 / 1-2期

关键词：

liquid crystals; clorhexidine base and salts; transmission electron microscopy; small-angle neutron scattering; membrane transport;

D O I：

10.1016/S0378-5173(00)00575-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The aim of this study was to investigate the influence of three chlorhexidine species, chlorhexidine base and its salts (diacetate and digluconate), on the physico-chemical features of liquid crystalline systems and on drug transport through lipophilic membranes. Nonionic surfactant, Synperonic A7 (PEG(7)-C13-15) was selected for the preparation of the liquid crystalline systems. Mixtures of different ratios of Synperonic A7 and water were prepared. The liquid crystalline systems were characterized using polarizing microscopy, small-angle neutron scattering and transmission electron microscopy. Membrane transport was also examined. The addition of chlorhexidine species to the liquid crystalline system modified the structure of the liquid crystalline system. As a result of liquid crystal-drug interaction, the solubility of chlorhexidine base and its diffusion through lipophilic membranes increased in comparison with those of the chlorhexidine salts. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：1 / 5

页数：5

共 8 条

[1] The effect of liquid crystalline structure on chlorhexidine diacetate release [J].