Calcium tsunamis: do astrocytes transmit cell death messages via gap junctions during ischemia?

被引：41

作者：

Budd, SL ^{[1
]}

Lipton, SA ^{[1
]}

机构：

[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, CNS Res Inst, Boston, MA 02115 USA

来源：

NATURE NEUROSCIENCE | 1998年 / 1卷 / 06期

关键词：

D O I：

10.1038/2147

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Apoptosis seems to be a dignified method of cell death, dictated by an individual cell, but new evidence that astrocytes can send apoptotic signals to neighboring cells through gap junctions challenges this model and may explain slowly spreading damage to glia after an ischemic insult.

引用

页码：431 / 432

页数：2

共 14 条

[1] GLUTAMATE-INDUCED NEURONAL DEATH - A SUCCESSION OF NECROSIS OR APOPTOSIS DEPENDING ON MITOCHONDRIAL-FUNCTION [J].

ANKARCRONA, M ;

DYPBUKT, JM ;

BONFOCO, E ;

ZHIVOTOVSKY, B ;

ORRENIUS, S ;

LIPTON, SA ;

NICOTERA, P .

NEURON, 1995, 15 (04) :961-973

[2]

Araque A, 1998, J NEUROSCI, V18, P6822

[3]

Blanc EM, 1998, J NEUROCHEM, V70, P958

[4] GLUTAMATE INDUCES CALCIUM WAVES IN CULTURED ASTROCYTES - LONG-RANGE GLIAL SIGNALING [J].

CORNELLBELL, AH ;

FINKBEINER, SM ;

COOPER, MS ;

SMITH, SJ .

SCIENCE, 1990, 247 (4941) :470-473

[5]

Cotrina ML, 1998, J NEUROSCI, V18, P2520

[6] GAP-JUNCTIONS IN THE BRAIN - WHERE, WHAT TYPE, HOW MANY AND WHY [J].

DERMIETZEL, R ;

SPRAY, DC .

TRENDS IN NEUROSCIENCES, 1993, 16 (05) :186-192

[7] CALCIUM WAVES IN ASTROCYTES FILLING IN THE GAPS [J].

FINKBEINER, S .

NEURON, 1992, 8 (06) :1101-1108

[8] An extracellular signaling component in propagation of astrocytic calcium waves [J].

Hassinger, TD ;

Guthrie, PB ;

Atkinson, PB ;

Bennett, MVL ;

Kater, SB .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (23) :13268-13273

[9] Intracellular adenosine triphosphate (ATP) concentration: A switch in the decision between apoptosis and necrosis [J].

Leist, M ;

Single, B ;

Castoldi, AF ;

Kuhnle, S ;

Nicotera, P .

JOURNAL OF EXPERIMENTAL MEDICINE, 1997, 185 (08) :1481-1486

[10] Gap-junction-mediated propagation and amplification of cell injury [J].

Lin, JHC ;

Weigel, H ;

Cotrina, ML ;

Liu, SJ ;

Bueno, E ;

Hansen, AJ ;

Hansen, TW ;

Goldman, S ;

Nedergaard, M .

NATURE NEUROSCIENCE, 1998, 1 (06) :494-500

← 1 2 →