Palladium-catalyzed nucleophilic benzylic substitutions of benzylic esters

被引：139

作者：

Kuwano, R ^{[1
]}

Kondo, Y ^{[1
]}

Matsuyama, Y ^{[1
]}

机构：

[1] Kyushu Univ, Grad Sch Sci, Dept Chem, Higashi Ku, Fukuoka 8128581, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2003年 / 125卷 / 40期

关键词：

D O I：

10.1021/ja037735z

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A palladium complex generated in situ from [Pd(η3-C3H5)(cod)]BF4 and DPPF is a good catalyst for benzylic alkylation of benzyl methyl carbonate with the carbanion of dimethyl malonates. The catalytic reaction is applicable to a wide range of the benzylations of benzylic esters with malonates. The catalytic activity was heavily affected by the bite angle of the bidentate phosphine ligand on palladium. DPEphos ligand is superior to DPPF in the case of palladium-catalyzed benzylic amination of benzylic esters. Copyright © 2003 American Chemical Society.

引用

页码：12104 / 12105

页数：2

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