Interaction of nanoparticles with lipid membrane

被引：310

作者：

Roiter, Yuri ^{[2
]}

Ornatska, Maryna ^{[2
]}

Rammohan, Aravind R. ^{[1
]}

Balakrishnan, Jitendra ^{[1
]}

Heine, David R. ^{[1
]}

Minko, Sergiy ^{[2
]}

机构：

[1] Corning Inc, Corning, NY 14831 USA

[2] Clarkson Univ, Dept Chem & Biomol Sci, Potsdam, NY 13699 USA

来源：

NANO LETTERS | 2008年 / 8卷 / 03期

关键词：

D O I：

10.1021/nl080080l

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A nanoscale range of surface feature curvatures where lipid membranes lose integrity and form pores has been found experimentally. The pores were experimentally observed in the L-alpha-dimyristoyl phosphatidylcholine membrane around 1.2-22 nm polar nanoparticles deposited on mica surface. Lipid bilayer envelops or closely follows surface features with the curvatures outside of that region. This finding provides essential information for the understanding of nanoparticle-lipid membrane interaction, cytotoxicity, preparation of biomolecular templates and supported lipid membranes on rough and patterned surfaces.

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收藏

页码：941 / 944

页数：4

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