Where do we stand on vascular calcification?

被引：46

作者：

Bostrom, Kristina I. ^{[1
,2
]}

机构：

[1] UCLA, David Geffen Sch Med, Div Cardiol, Box 951679, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Inst Mol Biol, Los Angeles, CA 90024 USA

来源：

VASCULAR PHARMACOLOGY | 2016年 / 84卷

关键词：

Vascular calcification; Review; Signaling pathway; Calcifying cells; SMOOTH-MUSCLE-CELLS; MATRIX GLA PROTEIN; AORTIC-VALVE DISEASE; ARTERIAL CALCIFICATION; DEFICIENT MICE; ARTERIOSCLEROTIC CALCIFICATION; ATHEROSCLEROTIC LESIONS; REGULATORY MECHANISMS; IN-VITRO; BONE;

D O I：

10.1016/j.vph.2016.05.014

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Vascular disease, such as atherosclerosis and diabetic vasculopathy, is frequently complicated by vascular calcification. Previously believed to be an end-stage process of unregulated mineral precipitation, it is now well established to be a multi-faceted disease influenced by the characteristics of its vascular location, the origins of calcifying cells and numerous regulatory pathways. It reflects the fundamental plasticity of the vasculature that is gradually being revealed by progress in vascular and stem cell biology. This review provides a brief overview of where we stand in our understanding of vascular calcification, facing the challenge of translating this knowledge into viable preventive and therapeutic strategies. (C) 2016 Elsevier Inc. All rights reserved.

引用

页码：8 / 14

页数：7

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