Recent advances in the development of human rhinovirus 3C protease inhibitors

被引：18

作者：

Dragovich, PS ^{[1
]}

机构：

[1] Agouron Pharmaceut Inc, La Jolla, CA 92037 USA

来源：

EXPERT OPINION ON THERAPEUTIC PATENTS | 2001年 / 11卷 / 02期

关键词：

3C protease; antirhinoviral agents; human rhinovirus; protease inhibitors;

D O I：

10.1517/13543776.11.2.177

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The human rhinoviruses (HRVs) are the most significant cause of the common cold. Important advances in the development of novel, broad spectrum antirhinoviral agents have recently been made by inhibiting the function of virally encoded enzymes essential for viral replication. This article summarises the most recent developments in the design of HRV 3C protease inhibitors which are intended for se as broad spectrum antirhinoviral therapeutic agents.

引用

页码：177 / 184

页数：8

共 52 条

[1] BIOLOGICALLY-ACTIVE PROTEASE 3C OF HUMAN RHINOVIRUS 1A IS EXPRESSED FROM A CLONED CDNA SEGMENT IN ESCHERICHIA-COLI [J].