CD36 deficiency associated with insulin resistance

被引：160

作者：

Miyaoka, K ^{[1
]}

Kuwasako, T ^{[1
]}

Hirano, K ^{[1
]}

Nozaki, S ^{[1
]}

Yamashita, S ^{[1
]}

Matsuzawa, Y ^{[1
]}

机构：

[1] Osaka Univ, GRad Sch Med, Dept Internal Med & Mol Sci, Suita, Osaka 5650871, Japan

来源：

LANCET | 2001年 / 357卷 / 9257期

关键词：

D O I：

10.1016/S0140-6736(00)04138-6

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

No major genes responsible for insulin resistance have yet been identified. CD36 is a multifunctional receptor, which plays a part in mediating intracellular signalling as well as in taking up biologically active substances such as long-chain fatty acids. We looked for insulin resistance in genetic CD36 deficiency, which is common in Asian and African populations, The euglycaemic hyperinsulinaemic clamp technique showed insulin resistance in the five CD36-deficient people tested, We conclude that CD36 could be responsible for insulin resistance.

引用

页码：686 / 687

页数：2

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