Perirhinal contributions to human visual perception

被引:81
作者
Devlin, Joseph T.
Price, Cathy J.
机构
[1] UCL, Dept Psychol, London WC1E 6BT, England
[2] UCL, Wellcome Trust Ctr Neuroimag, London WC1N 3BG, England
基金
英国惠康基金;
关键词
D O I
10.1016/j.cub.2007.07.066
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Medial temporal lobe (MTL) structures including the hippocampus, entorhinal cortex, and perirhinal cortex are thought to be part of a unitary system dedicated to memory [1, 2], although recent studies suggest that at least one component-perirhinal cortex-might also contribute to perceptual processing [3-6]. To date, the strongest evidence for this comes from animal lesion studies [7-14]. In contrast, the findings from human patients with naturally occurring MTL lesions are less clear and suggest a possible functional difference between species [15-20]. Here, both these issues were addressed with functional neuroimaging in healthy volunteers performing a perceptual discrimination task originally developed for monkeys [7]. This revealed perirhinal activation when the task required the integration of visual features into a view-invariant representation but not when it could be accomplished on the basis of simple features (e.g., color and shape). This activation pattern matched lateral inferotemporal regions classically associated with visual processing but differed from entorhinal cortex associated with memory encoding. The results demonstrate a specific role for the perirhinal cortex in visual perception and establish a functional homology for perirhinal cortex between species, although we propose that in humans, the region contributes to a wider behavioral repertoire including mnemonic, perceptual, and linguistic processes.
引用
收藏
页码:1484 / 1488
页数:5
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