An anti-inflammatory role for glucocorticoids in the ovaries?

Roles of glucocorticoids in the direct regulation of ovarian function are poorly understood. This opinion paper highlights: (1) the inflammatory nature of the ovulatory process; (2) the contributions of cytokines and prostaglandins thence inflammation) to ovulation; (3) the development-related pattern of 11 beta-hydroxysteroid (11 beta HSD) isoform expression thence glucocorticoid metabolism) that occurs in ovarian follicles; and (4) the attribution of general anti-inflammatory properties of glucocorticoids to their interference with prostaglandin synthesis. We interpret the evidence cited to hypothesise that corticosteroids serve an anti-inflammatory role during ovulation, thereby promoting rapid healing of the wound left by follicular rupture. Other possible levels of glucocorticoid action in the ovaries are also considered. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.