RecQ helicases: multiple roles in genome maintenance

被引：105

作者：

Khakhar, RR

Cobb, JA

Bjergbaek, L

Hickson, ID ^{[1
]}

Gasser, SM

机构：

[1] Univ Oxford, John Radcliffe Hosp, Canc Res UK Labs, Weatherall Inst Mol Med, Oxford OX3 9DS, England

[2] Univ Geneva, Dept Mol Biol, CH-1211 Geneva 4, Switzerland

来源：

TRENDS IN CELL BIOLOGY | 2003年 / 13卷 / 09期

关键词：

D O I：

10.1016/S0962-8924(03)00171-5

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The RecQ helicases are highly conserved in evolution and are required for maintaining genome stability in all organisms. In humans, loss of RecQ helicase function is associated with predisposition to cancer and/or premature ageing. Recent data show that RecQ helicases have several roles during S phase of the cell cycle, ranging from facilitating the resumption of DNA synthesis at sites of replication fork breakdown to resolving structures during the process of homologous recombination.

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页码：493 / 501

页数：9

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