Highly enantioselective dynamic kinetic resolution and desymmetrization processes by cyclocondensation of chiral aminoalcohols with racemic or prochiral δ-oxoacid derivatives

被引：31

作者：

Amat, M ^{[1
]}

Bassas, O

Pericàs, MA

Pastó, M

Bosch, J

机构：

[1] Univ Barcelona, Fac Pharm, Organ Chem Lab, E-08028 Barcelona, Spain

[2] Univ Barcelona, Dept Organ Chem, E-08028 Barcelona, Spain

来源：

CHEMICAL COMMUNICATIONS | 2005年 / 10期

关键词：

D O I：

10.1039/b413937b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Cyclocondensation reactions of aminoalcohols 7 and 8 with racemic or prochiral delta-oxoacid derivatives provide polysubstituted lactams with high enantioselectivity in a process that involves dynamic kinetic resolution and/or desymmetrization of enantiotopic or diastereotopic ester groups.

引用

页码：1327 / 1329

页数：3

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