Preparation and blood compatibility of new silica-chitosan hybrid biomaterials

被引：11

作者：

Chen, HM ^{[1
]}

Tian, XM ^{[1
]}

Zou, H ^{[1
]}

机构：

[1] Jinan Univ, Inst Biomed Engn, Guangzhou 510632, Peoples R China

来源：

ARTIFICIAL CELLS BLOOD SUBSTITUTES AND IMMOBILIZATION BIOTECHNOLOGY | 1998年 / 26卷 / 04期

基金：

中国国家自然科学基金;

关键词：

hybrid material; sol-gel process; blood compatibility;

D O I：

10.3109/10731199809117683

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The development of new materials containing both organic and inorganic structures is of great interest with respect to achievement of obtaining the special properties, and the sol-gel process has provided new opportunities for making such materials. In this paper, new silica-chitosan hybrid biomaterials were produced by this technique, using biopolymer chitosan and its heparin-like derivative as the organic species to be incorporated into the silicon alkoxide (TEOS) based network. All the samples made were in form of thin, flexible films with optical clarity Microphase separated structure was observed in the hybrid surface, with hydrophobic SiO2 and hydrophilic chitosan interleaved These hybrid materials displayed good blood compatibility in comparison with their single component Systems.

引用

页码：431 / 436

页数：6