Evidence of Person-to-Person Transmission of Oseltamivir-Resistant Pandemic Influenza A(H1N1) 2009 Virus in a Hematology Unit

被引：56

作者：

Moore, Catherine

Galiano, Monica

Lackenby, Angie ^{[7
]}

Abdelrahman, Tamer

Barnes, Rosemary ^{[4
]}

Evans, Meirion R. ^{[3
,5
]}

Fegan, Christopher ^{[2
]}

Froude, Susannah

Hastings, Mark

Knapper, Steven ^{[6
]}

Litt, Emma ^{[2
]}

Price, Nicola

Salmon, Roland ^{[3
]}

Temple, Mark ^{[3
]}

Davies, Eleri ^{[1
]}

机构：

[1] Publ Hlth Wales NHS Trust, Univ Wales Hosp, Cardiff CF14 4XW, S Glam, Wales

[2] Univ Wales Hosp, Dept Hematol, Cardiff CF4 4XW, S Glam, Wales

[3] Publ Hlth Wales NHS Trust, Ctr Communicable Dis Surveillance, Cardiff CF14 4XW, S Glam, Wales

[4] Cardiff Univ, Sch Med, Dept Infect Immun & Biochem, Cardiff, S Glam, Wales

[5] Cardiff Univ, Dept Publ Hlth & Primary Care, Cardiff, S Glam, Wales

[6] Cardiff Univ, Dept Hematol, Cardiff, S Glam, Wales

[7] Hlth Protect Agcy, Ctr Infect, Div Virus Reference, Resp Virus Unit, London, England

来源：

JOURNAL OF INFECTIOUS DISEASES | 2011年 / 203卷 / 01期

基金：

英国惠康基金;

关键词：

INFECTION;

D O I：

10.1093/infdis/jiq007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We describe the first confirmed person-to-person transmission of oseltamivir-resistant pandemic influenza A(H1N1) 2009 virus that occurred in a hematology unit in the United Kingdom. Eleven cases of (H1N1) 2009 virus infection were identified, of which, ten were related as shown by sequence analysis of the hemagglutinin and neuraminidase genes. H275Y analysis demonstrated that 8 of 10 case patients had oseltamivir-resistant virus, with 4 of 8 case patients infected by direct transmission of resistant virus. Zanamivir should be considered as first-line therapy for influenza in patients with lymphopenic hematological conditions and uptake of influenza vaccination encouraged to further reduce the number of susceptible individuals.

引用

页码：18 / 24

页数：7

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