Cationic DMPC/DMTAP lipid bilayers: Local lateral polarization of phosphatidylcholine headgroups

被引：16

作者：

Levadny, V

Yamazaki, M

机构：

[1] Shizuoka Univ, Fac Sci, Dept Phys, Shizuoka 4228529, Japan

[2] Russian Acad Sci, Sci Council Cybernet, Moscow 333117, Russia

来源：

LANGMUIR | 2005年 / 21卷 / 13期

关键词：

Computer simulation - Molecular dynamics - Molecular orientation - Molecules - Monte Carlo methods - Positive ions - Volume fraction;

D O I：

10.1021/la046976x

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We investigated the effect of dimyristoyltrimethylammonium propane (DMTAP) charge on area per molecule of mixed DMTAP/dimyristoylphosphatidylcholine (DMPC) bilayers in a simple model. Assuming that trimethylammonium (TAP) charge causes lateral polarization of neighboring PC molecules, we analyzed variation in area per molecule as the mole fraction of TAP increases. The theoretical predictions obtained in the present study are consistent with results of a recent molecular dynamics simulation study (Gurtovenko et al. Biophys. J. 2004, 86, 3461).

引用

页码：5677 / 5680

页数：4

共 5 条

[1] MEMBRANE ELECTROSTATICS [J].