The inhibitory effects of peripheral administration of peptide YY3-36 and glucagon-like peptide-1 on food intake are attenuated by ablation of the vagal-brainstem-hypothalamic pathway

被引：430

作者：

Abbott, CR ^{[1
]}

Monteiro, M ^{[1
]}

Small, CJ ^{[1
]}

Sajedi, A ^{[1
]}

Smith, KL ^{[1
]}

Parkinson, JRC ^{[1
]}

Ghatei, MA ^{[1
]}

Bloom, SR ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Endocrine Unit, London W12 0NN, England

来源：

BRAIN RESEARCH | 2005年 / 1044卷 / 01期

基金：

英国惠康基金;

关键词：

peptide YY; glucagon-like peptide-1; appetite; vagus nerve; brainstein; hypothalamus;

D O I：

10.1016/j.brainres.2005.03.011

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The vagus nerve forms a neuro-anatomical link between the gastrointestinal tract and the brain. A number of gastrointestinal hormones, including cholecystokinin and ghrelin, require an intact vagal-brainstem-hypothalamic pathway to affect CNS feeding circuits. We have, shown that the effects of peripheral administration of both peptide YY3-36 (PYY3-36) and glucagon-like peptide-1 (GLP-1) on food intake and activation of hypothalamic arcuate feeding neurotics are abolished following either bilateral sub-diaphragmatic total truncal vagotomy or brainstem-hypothalamic pathway transectioning in rodents. These findings suggest that the vagal-brainstem-hypothalamic pathway may also play a role in the effects of circulating PYY3-36 and GLP-1 on food intake. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：127 / 131

页数：5

共 22 条

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