Synthesis of doxorubicin conjugates through hydrazone bonds to melanotransferrin p97

被引：14

作者：

Chen, QQ ^{[1
]}

Sowa, DA ^{[1
]}

Cai, JL ^{[1
]}

Gabathuler, R ^{[1
]}

机构：

[1] Biomarin Pharmaceut Inc, Novato, CA 94949 USA

来源：

SYNTHETIC COMMUNICATIONS | 2003年 / 33卷 / 14期

关键词：

doxorubicin; bioconjugate; protein carrier; crosslinking; hydrazone linker; blood-brain barrier; drug delivery; anticancer drug; brain tumor;

D O I：

10.1081/SCC-120021827

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Through hydrazone bonds, three doxorubicin-p97 conjugates 5, 9, 12 are synthesized using adipic dihydrazine, 4-(4-N-maleimidophenyl)-butyric acid hydrazine 6 and adipic acid mono hydrazine 10 as linkers. These are potential agents for treating brain tumors.

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收藏

页码：2377 / 2390

页数：14

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