Genetic diversity and antigenic polymorphism in Plasmodium falciparum:: Extensive serological cross-reactivity between allelic variants of merozoite surface protein 2

被引:46
作者
Franks, S
Baton, L
Tetteh, K
Tongren, E
Dewin, D
Akanmori, BD
Koram, KA
Ranford-Cartwright, L
Riley, EM
机构
[1] Univ London London Sch Hyg & Trop Med, Dept Infect & Trop Dis, London WC1E 7HT, England
[2] Univ Edinburgh, Inst Cell Anim & Populat Biol, Edinburgh EH9 3JT, Midlothian, Scotland
[3] Univ Glasgow, Inst Biomed & Life Sci, Div Infect & Immun, Glasgow G12 8QQ, Lanark, Scotland
[4] Univ Ghana, Noguchi Mem Inst Med Res, Legon, Ghana
基金
英国惠康基金;
关键词
D O I
10.1128/IAI.71.6.3485-3495.2003
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Diversity in the surface antigens of malaria parasites is generally assumed to be a mechanism for immune evasion, but there is little direct evidence that this leads to evasion of protective immunity. Here we show that alleles of the highly polymorphic merozoite surface protein 2 (MSP-2) can be grouped (within the known dimorphic families) into distinct serogroups; variants within a serogroup show extensive serological cross-reactivity. Cross-reactive epitopes are immunodominant, and responses to them may be boosted at the expense of responses to novel epitopes (original antigenic sin). The data imply that immune selection explains only some of the diversity in the msp-2 gene and that MSP-2 vaccines may need to include only a subset of the known variants in order to induce pan-reactive antibodies.
引用
收藏
页码:3485 / 3495
页数:11
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