Transcription: Gene control by targeted histone acetylation

被引：117

作者：

Imhof, A ^{[1
]}

Wolffe, AP ^{[1
]}

机构：

[1] NICHD, Mol Embryol Lab, NIH, Bethesda, MD 20892 USA

来源：

CURRENT BIOLOGY | 1998年 / 8卷 / 12期

关键词：

D O I：

10.1016/S0960-9822(98)70268-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A transcriptional regulator in yeast, Gcn5p, activates transcription by targeted acetylation of specific lysine residues in the amino-terminal tails of histones, This targeted modification is restricted to nucleosomes assembled on the promoters of Gcn5p-responsive genes.

引用

页码：R422 / R424

页数：3

共 13 条

[1] Tetrahymena histone acetyltransferase A: A homolog to yeast Gcn5p linking histone acetylation to gene activation
Brownell, JE
Zhou, JX
Ranalli, T
Kobayashi, R
Edmondson, DG
Roth, SY
Allis, CD
[J]. CELL, 1996, 84 (06) : 843 - 851
[2] 2 DISTINCT YEAST TRANSCRIPTIONAL ACTIVATORS REQUIRE THE FUNCTION OF THE GCN5 PROTEIN TO PROMOTE NORMAL LEVELS OF TRANSCRIPTION
GEORGAKOPOULOS, T
THIREOS, G
[J]. EMBO JOURNAL, 1992, 11 (11) : 4145 - 4152
[3] Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain
Gu, W
Roeder, RG
[J]. CELL, 1997, 90 (04) : 595 - 606
[4] TRANSCRIPTIONAL COACTIVATORS IN YEAST AND BEYOND
GUARENTE, L
[J]. TRENDS IN BIOCHEMICAL SCIENCES, 1995, 20 (12) : 517 - 521
[5] Acetylation of general transcription factors by histone acetyltransferases
Imhof, A
Yang, XJ
Ogryzko, VV
Nakatani, Y
Wolffe, AP
Ge, H
[J]. CURRENT BIOLOGY, 1997, 7 (09) : 689 - 692
[6] Histone acetyltransferase activity of yeast Gcn5p is required for the activation of target genes in vivo
Kuo, MH
Zhou, JX
Jambeck, P
Churchill, MEA
Allis, CD
[J]. GENES & DEVELOPMENT, 1998, 12 (05) : 627 - 639
[7] Transcription-linked acetylation by Gcn5p of histones H3 and H4 at specific lysines
Kuo, MH
Brownell, JE
Sobel, RE
Ranalli, TA
Cook, RG
Edmondson, DG
Roth, SY
Allis, CD
[J]. NATURE, 1996, 383 (6597) : 269 - 272
[8] A POSITIVE ROLE FOR HISTONE ACETYLATION IN TRANSCRIPTION FACTOR ACCESS TO NUCLEOSOMAL DNA
LEE, DY
HAYES, JJ
PRUSS, D
WOLFFE, AP
[J]. CELL, 1993, 72 (01) : 73 - 84
[9] FUNCTIONAL SIMILARITY AND PHYSICAL ASSOCIATION BETWEEN GCN5 AND ADA2 - PUTATIVE TRANSCRIPTIONAL ADAPTERS
MARCUS, GA
SILVERMAN, N
BERGER, SL
HORIUCHI, J
GUARENTE, L
[J]. EMBO JOURNAL, 1994, 13 (20) : 4807 - 4815
[10] GENETIC-ANALYSIS OF HISTONE-H4 - ESSENTIAL ROLE OF LYSINES SUBJECT TO REVERSIBLE ACETYLATION
MEGEE, PC
MORGAN, BA
MITTMAN, BA
SMITH, MM
[J]. SCIENCE, 1990, 247 (4944) : 841 - 845

← 1 2 →