Disorders of frontal lobe functioning

被引:68
作者
Alexander, MP
Stuss, DT
机构
[1] Beth Israel Deaconess Med Ctr, Behav Neurol Unit, Boston, MA 02215 USA
[2] Harvard Univ, Sch Med, Boston, MA USA
[3] Baycrest Ctr Geriatr Care, Rotman Res Inst, Toronto, ON, Canada
[4] Univ Toronto, Dept Psychol, Toronto, ON M5S 1A1, Canada
[5] Univ Toronto, Dept Med Neurol Rehabil Sci, Toronto, ON M5S 1A1, Canada
关键词
frontal lobes; anatomy; functional specificity; assessment;
D O I
10.1055/s-2000-13175
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The neurology of frontal lobe disorders can be summarized in descriptions of behavioral problems (apathy, etc.), of cognitive impairments (poor planning, etc.), and of motor deficits (grasp reflex, etc.). Reviews of this sort do not indicate, however, any regional specificity to the deficit profiles or identify any of the component processes of the complex deficits-what exactly is "poor planning"? In this review we present specific steps that assist in overcoming the limitations: (1) identify weaknesses in current understanding, (2) operationally define the processes to be analyzed, (3) review some methodologies that allow parsing of discreet processes into specific frontal regions, (4) review the unique advantages and disadvantages of the various neurological disorders that provide us with subjects for study, and (5) propose approaches to advance further a useful clinical neurology of frontal robe disorders as well as a more finely grained scientific description of core frontal processes.
引用
收藏
页码:427 / 437
页数:11
相关论文
共 67 条
  • [1] ALEXANDER GE, 1990, PROG BRAIN RES, V85, P119
  • [2] FUNCTIONAL ARCHITECTURE OF BASAL GANGLIA CIRCUITS - NEURAL SUBSTRATES OF PARALLEL PROCESSING
    ALEXANDER, GE
    CRUTCHER, MD
    [J]. TRENDS IN NEUROSCIENCES, 1990, 13 (07) : 266 - 271
  • [3] PARALLEL ORGANIZATION OF FUNCTIONALLY SEGREGATED CIRCUITS LINKING BASAL GANGLIA AND CORTEX
    ALEXANDER, GE
    DELONG, MR
    STRICK, PL
    [J]. ANNUAL REVIEW OF NEUROSCIENCE, 1986, 9 : 357 - 381
  • [4] CAPGRAS SYNDROME - A REDUPLICATIVE PHENOMENON
    ALEXANDER, MP
    STUSS, DT
    BENSON, DF
    [J]. NEUROLOGY, 1979, 29 (03) : 334 - 339
  • [5] ALEXANDER MP, 1992, MOVEMENT DISORDERS N, P389
  • [6] WISCONSIN CARD SORTING TEST-PERFORMANCE AS A MEASURE OF FRONTAL-LOBE DAMAGE
    ANDERSON, SW
    DAMASIO, H
    JONES, RD
    TRANEL, D
    [J]. JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY, 1991, 13 (06) : 909 - 922
  • [7] [Anonymous], [No title captured]
  • [8] FRONTAL AMNESIA AND THE DYSEXECUTIVE SYNDROME
    BADDELEY, A
    WILSON, B
    [J]. BRAIN AND COGNITION, 1988, 7 (02) : 212 - 230
  • [9] Bechara A, 1998, J NEUROSCI, V18, P428
  • [10] INSENSITIVITY TO FUTURE CONSEQUENCES FOLLOWING DAMAGE TO HUMAN PREFRONTAL CORTEX
    BECHARA, A
    DAMASIO, AR
    DAMASIO, H
    ANDERSON, SW
    [J]. COGNITION, 1994, 50 (1-3) : 7 - 15