Bone mineral density in patients receiving suppressive doses of thyroxine for differentiated thyroid carcinoma

被引：42

作者：

Gorres, G ^{[1
]}

Kaim, A ^{[1
]}

Otte, A ^{[1
]}

Gotze, M ^{[1
]}

MullerBrand, J ^{[1
]}

机构：

[1] UNIV BASEL,KANTONSSPITAL,DEPT RADIOL,INST NUCL MED,CH-4031 BASEL,SWITZERLAND

来源：

EUROPEAN JOURNAL OF NUCLEAR MEDICINE | 1996年 / 23卷 / 06期

关键词：

bone mineral density drug effects; thyroxine therapeutic use; thyroid carcinoma drug therapy; osteoporosis epidemiology;

D O I：

10.1007/BF00834532

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

To determine bone mineral density in patients with differentiated thyroid carcinoma receiving thyroxine replacement therapy in suppressive doses, we studied 65 patients (47 women and 18 men; age 25-83 years, mean +/- SD 52.5 +/- 15.4 years). Patients were free of thyroid cancer in clinical and laboratory examinations at the time of the study. Bone mineral density of the lumbar spine and both hips was measured by dual-energy X-ray absorptiometry. There was no decrease in bone density in either 32 postmenopausal or 15 premenopausal women compared with an age- and sex-matched control group, nor was any decrease in bone density found in men. Our data suggest that thyroxine treatment in suppressive doses in patients with differentiated thyroid carcinoma is not a risk factor for the development of osteoporosis.

引用

页码：690 / 692

页数：3

共 9 条

[1] A THERAPEUTIC DILEMMA - SUPPRESSIVE DOSES OF THYROXINE SIGNIFICANTLY REDUCE BONE-MINERAL MEASUREMENTS IN BOTH PREMENOPAUSAL AND POSTMENOPAUSAL WOMEN WITH THYROID-CARCINOMA [J].

DIAMOND, T ;

NERY, L ;

HALES, I .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1991, 72 (06) :1184-1188

[2]

FLORKOWSKI CM, 1993, NEW ZEAL MED J, V106, P443

[3]

FRANKLYN JA, 1992, LANCET, V340, P435

[4]

HALL ML, 1991, EUR J NUCL MED, V18, P38

[5]

MCDERMOTT MT, 1983, CLIN ENDOCRINOL META, V369, P479

[6] RELATIVE CONTRIBUTIONS OF AGING AND ESTROGEN DEFICIENCY TO POSTMENOPAUSAL BONE LOSS [J].

RICHELSON, LS ;

WAHNER, HW ;

MELTON, LJ ;

RIGGS, BL .

NEW ENGLAND JOURNAL OF MEDICINE, 1984, 311 (20) :1273-1275

[7] INVOLUTIONAL OSTEOPOROSIS [J].

RIGGS, BL ;

MELTON, LJ .

NEW ENGLAND JOURNAL OF MEDICINE, 1986, 314 (26) :1676-1686

[8] IMPACT OF THERAPY FOR DIFFERENTIATED CARCINOMA OF THE THYROID - AN ANALYSIS OF 706 CASES [J].

SAMAAN, NA ;

MAHESHWARI, YK ;

NADER, S ;

HILL, CS ;

SCHULTZ, PN ;

HAYNIE, TP ;

HICKEY, RC ;

CLARK, RL ;

GEOPFERT, H ;

IBANEZ, ML ;

LITTON, CE .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1983, 56 (06) :1131-1138

[9] ACCELERATED BONE LOSS IN HYPOTHYROID PATIENTS OVERTREATED WITH L-THYROXINE [J].

STALL, GM ;

HARRIS, S ;

SOKOLL, LJ ;

DAWSONHUGHES, B .

ANNALS OF INTERNAL MEDICINE, 1990, 113 (04) :265-269

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