Cx43 gap junctions in cardiac development

被引：29

作者：

Lo, CW ^{[1
]}

Wessels, A

机构：

[1] Univ Penn, Goodard Lab, Dept Biol, Philadelphia, PA 19104 USA

[2] Med Univ S Carolina, Dept Anat & Cell Biol, Charleston, SC 29425 USA

来源：

TRENDS IN CARDIOVASCULAR MEDICINE | 1998年 / 8卷 / 06期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

D O I：

10.1016/S1050-1738(98)00018-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Studies utilizing knockout and transgenic mouse models revealed an important role for connexin 43 (Cx43) gap junctions in cardiac development.. This may involve a quantitative requirement for gap junctions in modulating the development of cardiac crest cells. In addition, studies in humans and Xenopus indicate that Cx43 gap junctions also may play a role in regulating heart laterality. Together, these findings indicate that the perturbation of Cx43 function could play a significant role in specific congenital heart malformations. (C) 1998, Elsevier Science Inc.

引用

页码：264 / 269

页数：6

共 41 条

[1]

BANCROFT M, 1976, ZOON (Uppsala), V4, P73

[2] CONNEXIN FAMILY OF GAP JUNCTION PROTEINS [J].

BEYER, EC ;

PAUL, DL ;

GOODENOUGH, DA .

JOURNAL OF MEMBRANE BIOLOGY, 1990, 116 (03) :187-194

[3] MUTATIONS OF THE CONNEXIN43 GAP-JUNCTION GENE IN PATIENTS WITH HEART MALFORMATIONS AND DEFECTS OF LATERALITY [J].

BRITZCUNNINGHAM, SH ;

SHAH, MM ;

ZUPPAN, CW ;

FLETCHER, WH .

NEW ENGLAND JOURNAL OF MEDICINE, 1995, 332 (20) :1323-1329

[4] Connections with connexins: The molecular basis of direct intercellular signaling [J].

Bruzzone, R ;

White, TW ;

Paul, DL .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1996, 238 (01) :1-27

[5]

Conway SJ, 1997, DEVELOPMENT, V124, P505

[6]

DAVIS EM, 1981, J EMBRYOL EXP MORPH, V63, P29

[7]

Ewart JL, 1997, DEVELOPMENT, V124, P1281

[8] DIFFERENTIATION OF CARDIAC CONDUCTING CELLS FROM THE NEURAL CREST [J].

FILOGAMO, G ;

CORVETTI, G ;

DANEO, LS .

JOURNAL OF THE AUTONOMIC NERVOUS SYSTEM, 1990, 30 :S55-S58

[9]

FILOGAMO G, 1995, CARDIOSCIENCE, V6, P19

[10] Regionalized transcriptional domains of myosin light chain 3f transgenes in the embryonic mouse heart: Morphogenetic implications [J].

Franco, D ;

Kelly, R ;

Lamers, WH ;

Buckingham, M ;

Moorman, AFM .

DEVELOPMENTAL BIOLOGY, 1997, 188 (01) :17-33

← 1 2 3 4 5 →