Levodopa pharmacokinetics and dyskinesias: are there sex-related differences?

被引：47

作者：

Martinelli, P ^{[1
]}

Contin, M ^{[1
]}

Scaglione, C ^{[1
]}

Riva, R ^{[1
]}

Albani, F ^{[1
]}

Baruzzi, A ^{[1
]}

机构：

[1] Univ Bologna, Dipartimento Sci Neurol, Bologna, Italy

来源：

NEUROLOGICAL SCIENCES | 2003年 / 24卷 / 03期

关键词：

Body Weight; Plasma Concentration; Levodopa; Oral Dose; Time Curve;

D O I：

10.1007/s10072-003-0125-z

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We examined the potential sex-related differences in levodopa pharmacokinetics and their relation with the presence of dyskinesias in a group of 115 patients (67 men, 49 women) with Parkinson's disease. The patients were given a standard oral dose of levodopa plus benserazide (100/25 mg). The area under the levodopa plasma concentration time curve, corrected for the levodopa test dose (in mg/kg body weight), (AUC(w)) was significantly higher in women than in men, with a reduced oral clearance. No difference in the proportion of men and women experiencing dyskinesias was observed.

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页码：192 / 193

页数：2

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