Ubiquitin signals in the NF-κB pathway

被引：29

作者：

Terzic, J.

Marinovic-Terzic, I.

Ikeda, F.

Dikic, I.

机构：

[1] Univ Split, Split Med Sch, Dept Immunol, Split 21000, Croatia

[2] Univ Frankfurt, Sch Med, Inst Biochem 2, D-60590 Frankfurt, Germany

[3] Mediterranean Inst Life Sci, Split 21000, Croatia

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2007年 / 35卷

关键词：

de-ubiquitinating enzyme; inhibitory kappa B kinase (IKK); nuclear factor kappa B (NF-kappa B); transcription factor; tumour necrosis factor receptor (TNFR); ubiquitination;

D O I：

10.1042/BST0350942

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The NF-kappa B (nuclear factor kappa B) transcription factors control cell survival, proliferation and innate and adaptive immune response. Post-translational modifications of key components of the NF-kappa B pathway provide the molecular basis for signal transmission from the cell membrane to the nucleus. Here, we describe the involvement of different types of ubiquitin modification in the regulation of the NF-kappa B signalling pathway.

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页码：942 / 945

页数：4

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