Novel crystalline catalysts

被引：135

作者：

Margolin, AL

机构：

来源：

TRENDS IN BIOTECHNOLOGY | 1996年 / 14卷 / 07期

关键词：

D O I：

10.1016/0167-7799(96)10031-7

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Cross-Linked Enzyme Crystals (CLEC(R)) offer a combination of features normally associated with either enzymes (high activity and selectivity, ability to function under mild reaction conditions, ease of disposal) or heterogeneous catalysts (stability in different environments, recycling). This combined set of properties makes CLEC catalysts extremely useful in organic synthesis. CLEC technology is broadly applicable to a wide variety of proteins, and may be useful in other areas, such as therapeutic-protein delivery, cosmetics and detergents, which can benefit from highly stable, active and pure proteins.

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页码：223 / 230

页数：8

相关论文

共 44 条

[1] KINETIC-PROPERTIES OF CARBOXYPEPTIDASE-B IN SOLUTIONS AND CRYSTALS [J].

ALTER, GM ;

LEUSSING, DL ;

NEURATH, H ;

VALLEE, BL .

BIOCHEMISTRY, 1977, 16 (16) :3663-3668

[2] PROTEIN DATA BANK - COMPUTER-BASED ARCHIVAL FILE FOR MACROMOLECULAR STRUCTURES [J].

BERNSTEIN, FC ;

KOETZLE, TF ;

WILLIAMS, GJB ;

MEYER, EF ;

BRICE, MD ;

RODGERS, JR ;

KENNARD, O ;

SHIMANOUCHI, T ;

TASUMI, M .

JOURNAL OF MOLECULAR BIOLOGY, 1977, 112 (03) :535-542

[3] Flexibility of enzymes suspended in organic solvents probed by time-resolved fluorescence anisotropy. Evidence that enzyme activity and enantioselectivity are directly related to enzyme flexibility [J].

Broos, J ;

Visser, AJWG ;

Engbersen, JFJ ;

Verboom, W ;

vanHoek, A ;

Reinhoudt, DN .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1995, 117 (51) :12657-12663

[4] MECHANISM OF PANCREATIC LIPASE ACTION .1. INTERFACIAL ACTIVATION OF PANCREATIC LIPASE [J].

CHAPUS, C ;

SEMERIVA, M ;

BOVIERLAPIERRE, C ;

DESNUELLE, P .

BIOCHEMISTRY, 1976, 15 (23) :4980-4987

[5] ENZYME ENGINEERING FOR NONAQUEOUS SOLVENTS - RANDOM MUTAGENESIS TO ENHANCE ACTIVITY OF SUBTILISIN-E IN POLAR ORGANIC MEDIA [J].

CHEN, KQ ;

ARNOLD, FH .

BIO-TECHNOLOGY, 1991, 9 (11) :1073-1077

[6]

DOSCHER MS, 1963, J BIOL CHEM, V238, P2399

[7] INACTIVATION OF ORGANOPHOSPHORUS NERVE AGENTS BY THE PHOSPHOTRIESTERASE FROM PSEUDOMONAS-DIMINUTA [J].

DUMAS, DP ;

DURST, HD ;

LANDIS, WG ;

RAUSHEL, FM ;

WILD, JR .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1990, 277 (01) :155-159

[8]

GOVARDHAN CP, 1995, CHEM IND, V17, P689

[9] BIODEGRADABLE LONG-CIRCULATING POLYMERIC NANOSPHERES [J].

GREF, R ;

MINAMITAKE, Y ;

PERACCHIA, MT ;

TRUBETSKOY, V ;

TORCHILIN, V ;

LANGER, R .

SCIENCE, 1994, 263 (5153) :1600-1603

[10]

GRIMSLEY JK, BIOREMEDIATION PRINC

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