The neurotrophic receptor TrkB in anoikis resistance and metastasis: A prespective

被引：63

作者：

Geiger, TR ^{[1
]}

Peeper, DS ^{[1
]}

机构：

[1] Netherlands Canc Inst, Div Mol Genet, NL-1066 CX Amsterdam, Netherlands

来源：

CANCER RESEARCH | 2005年 / 65卷 / 16期

关键词：

D O I：

10.1158/0008-5472.CAN-05-0709

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Resistance to anoikis ("detachment-induced apoptosis") has been suggested to be a prerequisite for cancer cells to metastasize. In a functional screen for suppressors of anoikis, we identified the neurotrophic receptor TrkB. Upon s.c. inoculation in mice, TrkB-expressing cells formed highly invasive and metastatic tumors. Here, we discuss our findings within the context of the proposed role of TrkB in human malignancies and address the question of its feasibility as a target for cancer therapy.

引用

页码：7033 / 7036

页数：4

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