Effect of the herbicide 4-CPA on human erythrocyte antioxidant enzymes in vitro

被引：4

作者：

Alicigüzel, Y

Özdem, S

Demir, AY

Ünal, F

Kumbul, D

Özdem, SS

Perry, G

Smith, MA

机构：

[1] Akdeniz Univ, Fac Med, Dept Biochem, TR-07070 Arapsuyu, Antalya, Turkey

[2] Akdeniz Univ, Fac Med, Dept Pharmacol, TR-07070 Arapsuyu, Antalya, Turkey

[3] Case Western Reserve Univ, Inst Pathol, Cleveland, OH 44106 USA

来源：

REDOX REPORT | 2001年 / 6卷 / 03期

关键词：

D O I：

10.1179/135100001101536256

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To investigate the possible role of oxygen free radicals and oxidant stress in the toxic effects of phenoxyherbicides. we studied the in vitro effect of 4-chlorophenoxyacetic acid (4-CPA) on various human erythrocyte antioxidant enzymes, namely glucose-6-phosphate dehydrogenase, catalase, selenium-dependent glutathione peroxidase, glutathione reductase and Cu/Zn-superoxide dismutase. 4-CPA added in a dose of 1 ppm to human erythrocytes for 1 h caused a significant reduction in glucose-6-phosphate dehydrogenase (P <0.001) and catalase (P <0.001) activities, but did not significantly affect the activities of other enzymes. Such selective inactivation of specific erythrocyte antioxidant enzymes may play a role in the toxic effects of phenoxyherbicides.

引用

页码：153 / 154

页数：2

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