Phaeochromocytoma: current concepts

被引：18

作者：

Alderazi, Y

Yeh, MW

Robinson, BG

Benn, DE

Sywak, MS

Learoyd, DL

Delbridge, LW

Sidhu, SB ^{[1
]}

机构：

[1] Royal N Shore Hosp, Dept Surg, St Leonards, NSW 2065, Australia

[2] Univ Sydney, Sydney, NSW 2006, Australia

来源：

MEDICAL JOURNAL OF AUSTRALIA | 2005年 / 183卷 / 04期

关键词：

D O I：

10.5694/j.1326-5377.2005.tb06997.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The discovery of novel mutations in genes encoding succinate dehydrogenase subunits has revealed that familial phaeochromocytomas are much more common than previously thought. Genetic screening should be offered to patients with apparently sporadic phaeochromocytomas and their first-degree relatives. An increasing proportion of phaeochromocytomas present preclinically on genetic testing or as "incidentalomas" on abdominal imaging, rather than with classic symptoms and signs. Clinical suspicion should prompt measurement of plasma levels of free metanephrine or 24-hour urinary catecholamine and metanephrine levels, followed, if positive, by tumour localisation studies. With appropriate perioperative care, surgical management of phaeochromocytomas is safe and effective. Most tumours can be removed laparoscopically.

引用

收藏

页码：201 / 204

页数：4

相关论文

共 29 条

[1] Germline SDHD mutation in familial phaeochromocytoma [J].

Astuti, D ;

Douglas, F ;

Lennard, TWJ ;

Aligianis, IA ;

Woodward, ER ;

Evans, DGR ;

Eng, C ;

Latif, F ;

Maher, ER .

LANCET, 2001, 357 (9263) :1181-1182

[2] Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paraganglioma [J].

Astuti, D ;

Latif, F ;

Dallol, A ;

Dahia, PLM ;

Douglas, F ;

George, E ;

Sköldberg, F ;

Husebye, ES ;

Eng, C ;

Maher, ER .

AMERICAN JOURNAL OF HUMAN GENETICS, 2001, 69 (01) :49-54

[3] Novel succinate dehydrogenase subunit B (SDHB) mutations in familial phaeochromocytomas and paragangliomas, but an absence of somatic SDHB mutations in sporadic phaeochromocytomas [J].

Benn, DE ;

Croxson, MS ;

Tucker, K ;

Bambach, CP ;

Richardson, AL ;

Delbridge, L ;

Pullan, PT ;

Hammond, J ;

Marsh, DJ ;

Robinson, BG .

ONCOGENE, 2003, 22 (09) :1358-1364

[4] Laparoscopic adrenalectomy for pheochromocytoma [J].

Cheah, WK ;

Clark, OH ;

Horn, JK ;

Siperstein, AE ;

Duh, QY .

WORLD JOURNAL OF SURGERY, 2002, 26 (08) :1048-1051

[5] Pheochromocytoma - Death of an axiom. [J].

Dluhy, RG .

NEW ENGLAND JOURNAL OF MEDICINE, 2002, 346 (19) :1486-1488

[6] Editorial: Evolving surgical management for patients with pheochromocytoma [J].

Duh, QY .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2001, 86 (04) :1477-1479

[7] Malignant pheochromocytoma: current status and initiatives for future progress [J].

Eisenhofer, G ;

Bornstein, SR ;

Brouwers, FM ;

Cheung, NKV ;

Dahia, PL ;

de Krijger, RR ;

Giordano, TJ ;

Greene, LA ;

Goldstein, DS ;

Lehnert, H ;

Manger, WM ;

Maris, JM ;

Neumann, HPH ;

Pacak, K ;

Shulkin, BL ;

Smith, DI ;

Tischler, AS ;

Young, WF .

ENDOCRINE-RELATED CANCER, 2004, 11 (03) :423-436

[8] Biochemical diagnosis of pheochromocytoma: How to distinguish true- from false-positive test results [J].

Eisenhofer, G ;

Goldstein, DS ;

Walther, MM ;

Friberg, P ;

Lenders, JWM ;

Keiser, HR ;

Pacak, K .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2003, 88 (06) :2656-2666

[9] Ki-67 and hTERT expression can aid in the distinction between malignant and benign pheochromocytoma and paraganglioma [J].

Elder, EE ;

Xu, D ;

Höög, A ;

Enberg, U ;

Pisa, P ;

Gruber, A ;

Larsson, C ;

Bäckdahl, M .

MODERN PATHOLOGY, 2003, 16 (03) :246-255

[10] The management of benign and malignant pheochromocytoma and abdominal paraganglioma [J].

Elder, EE ;

Skog, ALH ;

Höög, A ;

Hamberger, B .

EUROPEAN JOURNAL OF SURGICAL ONCOLOGY, 2003, 29 (03) :278-283