Mitochondrial DNA haplogroup cluster UKJT reduces the risk of PD

被引：141

作者：

Pyle, A

Foltynie, T

Tiangyou, W

Lambert, C

Keers, SM

Allcock, LM

Davison, J

Lewis, SJ

Perry, RH

Barker, R

Burn, DJ

Chinnery, PF

机构：

[1] Newcastle Univ, Mitochondrial Res Grp, Sch Med, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

[2] Univ Cambridge, Cambridge Ctr Brain Repair, Cambridge, England

[3] Sunderland Royal Hosp, Dept Neurol, Sunderland, England

[4] Newcastle Univ, Inst Ageing & Hlth, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

[5] Reg Neurosci Ctr, Dept Neurol, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

来源：

ANNALS OF NEUROLOGY | 2005年 / 57卷 / 04期

关键词：

D O I：

10.1002/ana.20417

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

There is increasing evidence that genetic variants of mitochondrial DNA have an important role in the cause of idiopathic Parkinson's disease. We determined the mitochondrial DNA haplogroup of 455 Parkinson's disease cases, 185 Alzheimer's disease cases, and 447 healthy English control subjects. The UKJT haplogroup duster was associated with a 22% reduction in population-attributable risk for Parkinson's disease. There was no association between individual haplogroups or the UKJT cluster and Alzheimer's disease, confirming that the association with Parkinson's disease was disease specific and not a general effect seen in all neurodegenerative diseases.

引用

收藏

页码：564 / 567

页数：4

相关论文

共 20 条

[1]

Armitage P., 2002, STAT METHODS MED RES

[2] Mitochondrial DNA polymorphisms as risk factors for Parkinson's disease and Parkinson's disease dementia [J].

Autere, J ;

Moilanen, JS ;

Finnilä, S ;

Soininen, H ;

Mannermaa, A ;

Hartikainen, P ;

Hallikainen, M ;

Majamaa, K .

HUMAN GENETICS, 2004, 115 (01) :29-35

[3] Chronic systemic pesticide exposure reproduces features of Parkinson's disease [J].

Betarbet, R ;

Sherer, TB ;

MacKenzie, G ;

Garcia-Osuna, M ;

Panov, AV ;

Greenamyre, JT .

NATURE NEUROSCIENCE, 2000, 3 (12) :1301-1306

[4] Mitochondrial DNA haplogroups and susceptibility to AD and dementia with Lewy bodies [J].

Chinnery, PF ;

Taylor, GA ;

Howell, N ;

Andrews, RM ;

Morris, CM ;

Taylor, RW ;

McKeith, IG ;

Perry, RH ;

Edwardson, JA ;

Turnbull, DM .

NEUROLOGY, 2000, 55 (02) :302-304

[5] Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death [J].

Darios, F ;

Corti, O ;

Lücking, CB ;

Hampe, C ;

Muriel, MP ;

Abbas, N ;

Gu, WJ ;

Hirsch, EC ;

Rooney, T ;

Ruberg, M ;

Brice, A .

HUMAN MOLECULAR GENETICS, 2003, 12 (05) :517-526

[6] Phylogenetic network for European mtDNA [J].

Finnilä, S ;

Lehtonen, MS ;

Majamaa, K .

AMERICAN JOURNAL OF HUMAN GENETICS, 2001, 68 (06) :1475-1484

[7] THE RELEVANCE OF THE LEWY BODY TO THE PATHOGENESIS OF IDIOPATHIC PARKINSONS-DISEASE [J].

GIBB, WRG ;

LEES, AJ .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1988, 51 (06) :745-752

[8] Reduced-median-network analysis of complete mitochondrial DNA coding-region sequences for the major African, Asian, and European haplogroups [J].

Herrnstadt, C ;

Elson, JL ;

Fahy, E ;

Preston, G ;

Turnbull, DM ;

Anderson, C ;

Ghosh, SS ;

Olefsky, JM ;

Beal, MF ;

Davis, RE ;

Howell, N .

AMERICAN JOURNAL OF HUMAN GENETICS, 2002, 70 (05) :1152-1171

[9] The emerging tree of west Eurasian mtDNAs:: A synthesis of control-region sequences and RFLPs [J].

Macaulay, V ;

Richards, M ;

Hickey, E ;

Vega, E ;

Cruciani, F ;

Guida, V ;

Scozzari, R ;

Bonné-Tamir, B ;

Sykes, B ;

Torroni, A .

AMERICAN JOURNAL OF HUMAN GENETICS, 1999, 64 (01) :232-249

[10] INHIBITION OF NADH-LINKED OXIDATION IN BRAIN MITOCHONDRIA BY 1-METHYL-4-PHENYL-PYRIDINE, A METABOLITE OF THE NEUROTOXIN, 1-METHYL-4-PHENYL-1,2,5,6-TETRAHYDROPYRIDINE [J].

NICKLAS, WJ ;

VYAS, I ;

HEIKKILA, RE .

LIFE SCIENCES, 1985, 36 (26) :2503-2508