CARD15/NOD2 analysis in rheumatoid arthritis susceptibility

被引：17

作者：

Ferreirós-Vidal, I

Barros, F

Pablos, JL

Carracedo, A

Gómez-Reino, JJ

Gonzalez, A ^{[1
]}

机构：

[1] Hosp Clin Univ Santiago, Lab Invest 2, Res Lab 2, Santiago De Compostela 15706, Spain

[2] Hosp Clin Univ Santiago, Rheumatol Unit, Santiago De Compostela, Spain

[3] Hosp 12 Octubre, Rheumatol Unit, E-28041 Madrid, Spain

[4] Univ Santiago de Compostela, Mol Med Unit, INGO, Santiago De Compostela, Spain

来源：

RHEUMATOLOGY | 2003年 / 42卷 / 11期

关键词：

rheumatoid arthritis; Crohn's disease; genetic predisposition to disease; autoimmune diseases;

D O I：

10.1093/rheumatology/keg383

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective. To determine if the mutations in the CARD15/NOD2 gene predisposing to Crohn's disease (CD) contribute also to the genetic susceptibility to rheumatoid arthritis (RA). Methods. The frequencies of the three commonest mutations of CARD15/NOD2 predisposing to CD (2104C > T, 2722G>C and 3020insC) were determined in 210 RA patients and 227 controls. Results. Allelic frequencies of the CARD15/NOD2 mutations in RA patients (2104C>T, 2.8%; 2722G>C, 0.9%; and 3020insC, 2.4%) did not differ significantly from the controls (2104C>T, 5.3%; 2722G>C, 0.7%; and 3020insC, 1.1%). Conclusion. There was no evidence of association between the commonest CD CARD15/NOD2 mutations and RA susceptibility.

引用

页码：1380 / 1382

页数：3

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