Disruption of cell adhesion in Xenopus embryos by Pagliaccio, an Eph-class receptor tyrosine kinase

被引：71

作者：

Winning, RS ^{[1
]}

Scales, JB ^{[1
]}

Sargent, TD ^{[1
]}

机构：

[1] NICHHD,MOL GENET LAB,NIH,BETHESDA,MD 20892

来源：

DEVELOPMENTAL BIOLOGY | 1996年 / 179卷 / 02期

关键词：

D O I：

10.1006/dbio.1996.0262

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Pagliaccio (Pag) is a receptor tyrosine kinase of the Eph family that is expressed in Xenopus embryos in a diverse set of localized tissues. Fag is the Xenopus homolog of Hek-8 (human), Sek-1 (mouse), cek8 (chicken), and RTK-1 (zebrafish). We have investigated the function of this protein by injecting RNA encoding an epidermal growth factor receptor-Fag chimera into early Xenopus embryos. Activation of the chimeric receptor results in a kinase-dependent loss of cell-cell adhesion. This dissociation can be reversed by co-injection of RNA encoding C-cadherin, suggesting that one or more cadherins could be the functional targets for Fag activity. (C) 1996 Academic Press, Inc.

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页码：309 / 319

页数：11

相关论文

共 39 条

[1] B61 IS A LIGAND FOR THE ECK RECEPTOR PROTEIN-TYROSINE KINASE [J].

BARTLEY, TD ;

HUNT, RW ;

WELCHER, AA ;

BOYLE, WJ ;

PARKER, VP ;

LINDBERG, RA ;

LU, HS ;

COLOMBERO, AM ;

ELLIOTT, RL ;

GUTHRIE, BA ;

HOLST, PL ;

SKRINE, JD ;

TOSO, RJ ;

ZHANG, M ;

FERNANDEZ, E ;

TRAIL, G ;

VARNUM, B ;

YARDEN, Y ;

HUNTER, T ;

FOX, GM .

NATURE, 1994, 368 (6471) :558-560

[2] MOLECULAR CHARACTERIZATION OF A FAMILY OF LIGANDS FOR EPH-RELATED TYROSINE KINASE RECEPTORS [J].

BECKMANN, MP ;

CERRETTI, DP ;

BAUM, P ;

VANDENBOS, T ;

JAMES, L ;

FARRAH, T ;

KOZLOSKY, C ;

HOLLINGSWORTH, T ;

SHILLING, H ;

MARASKOVSKY, E ;

FLETCHER, FA ;

LHOTAK, V ;

PAWSON, T ;

LYMAN, SD .

EMBO JOURNAL, 1994, 13 (16) :3757-3762

[3] MEMBRANE-BOUND LERK2 LIGAND CAN SIGNAL THROUGH 3 DIFFERENT EPH-RELATED RECEPTOR TYROSINE KINASES [J].

BRAMBILLA, R ;

SCHNAPP, A ;

CASAGRANDA, F ;

LABRADOR, JP ;

BERGEMANN, AD ;

FLANAGAN, JG ;

PASQUALE, EB ;

KLEIN, R .

EMBO JOURNAL, 1995, 14 (13) :3116-3126

[4] IDENTIFICATION AND CLONING OF ELF-1, A DEVELOPMENTALLY EXPRESSED LIGAND FOR THE MEK4 AND SEK RECEPTOR TYROSINE KINASES [J].

CHENG, HJ ;

FLANAGAN, JG .

CELL, 1994, 79 (01) :157-168

[5] COMPLEMENTARY GRADIENTS IN EXPRESSION AND BINDING OF ELF-1 AND MEK4 IN DEVELOPMENT OF THE TOPOGRAPHIC RETINOTECTAL PROJECTION MAP [J].

CHENG, HJ ;

NAKAMOTO, M ;

BERGEMANN, AD ;

FLANAGAN, JG .

CELL, 1995, 82 (03) :371-381

[6] LIGANDS FOR EPH-RELATED RECEPTOR TYROSINE KINASES THAT REQUIRE MEMBRANE ATTACHMENT OR CLUSTERING FOR ACTIVITY [J].

DAVIS, S ;

GALE, NW ;

ALDRICH, TH ;

MAISONPIERRE, PC ;

LHOTAK, V ;

PAWSON, T ;

GOLDFARB, M ;

YANCOPOULOS, GD .

SCIENCE, 1994, 266 (5186) :816-819

[7] IN-VITRO GUIDANCE OF RETINAL GANGLION-CELL AXONS BY RAGS, A 25 KDA TECTAL PROTEIN RELATED TO LIGANDS FOR EPH RECEPTOR TYROSINE KINASES [J].

DRESCHER, U ;

KREMOSER, C ;

HANDWERKER, C ;

LOSCHINGER, J ;

NODA, M ;

BONHOEFFER, F .

CELL, 1995, 82 (03) :359-370

[8] REPLACEMENT OF LYSINE RESIDUE 1030 IN THE PUTATIVE ATP-BINDING REGION OF THE INSULIN-RECEPTOR ABOLISHES INSULIN-STIMULATED AND ANTIBODY-STIMULATED GLUCOSE-UPTAKE AND RECEPTOR KINASE-ACTIVITY [J].

EBINA, Y ;

ARAKI, E ;

TAIRA, M ;

SHIMADA, F ;

MORI, M ;

CRAIK, CS ;

SIDDLE, K ;

PIERCE, SB ;

ROTH, RA ;

RUTTER, WJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (03) :704-708

[9]

FOX GM, 1995, ONCOGENE, V10, P897

[10]

GILARDIHEBENSTREIT P, 1992, ONCOGENE, V7, P2499

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