A 2,7-carbazole-based dicationic salt for fluorescence detection of nucleic acids and two-photon fluorescence imaging of RNA in nucleoli and cytoplasm

被引：73

作者：

Liu, Xin ^{[1
]}

Sun, Yuming ^{[2
]}

Zhang, Yuanhong ^{[1
]}

Miao, Fang ^{[1
]}

Wang, Guancong ^{[1
]}

Zhao, Hongshi ^{[1
]}

Yu, Xiaoqiang ^{[1
]}

Liu, Hong ^{[1
]}

Wong, Wai-Yeung ^{[3
,4
]}

机构：

[1] Shandong Univ, State Key Lab Crystal Mat, Jinan 250100, Peoples R China

[2] Shandong Univ, Sch Informat Sci & Engn, Jinan 250100, Peoples R China

[3] Univ Grants Comm, Areas Excellence Scheme, Hong Kong, Hong Kong, Peoples R China

[4] Hong Kong Baptist Univ, Dept Chem, Kowloon Tong, Hong Kong, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2011年 / 9卷 / 10期

基金：

美国国家科学基金会;

关键词：

DNA-BINDING; PROBE; LIVE; CELLS; EXCITATION; DERIVATIVES; MICROSCOPY;

D O I：

10.1039/c1ob05123g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new carbazole-derived dicationic compound, namely 2,7-bis(1-hydroxyethyl-4-vinylpyridinium iodine)-N-ethyl-carbazole (2,7-9E-BHVC), with a large two-photon action absorption cross section in nucleic acids has been obtained. Moreover, it possesses the potential of imaging RNA in nucleoli and cytoplasm in two-photon fluorescence microscopy and exhibits good counterstain compatibility with the commercial fluorescent nucleic dye DAPI.

引用

页码：3615 / 3618

页数：4

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