A Toll for lupus

被引：55

作者：

Anders, HJ ^{[1
]}

机构：

[1] LMU, Med Poliklin, D-80336 Munich, Germany

来源：

LUPUS | 2005年 / 14卷 / 06期

关键词：

autoimmunity; DNA; infection; inflammation; kidney;

D O I：

10.1191/0961203305lu2102rr

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Toll-like receptor (TLR)-9 recognizes CpG motifs in microbial DNA. TLR9 signalling stimulates innate antimicrobial immunity and modulates adaptive immune responses including autoimmunity against chromatin, e.g., in systemic lupus erythematosus (SLE). This review summarizes the available data for a role of TLR9 signalling in lupus and discusses the following questions that arise from these observations: 1) Is CpG-DNA/TLR9 interaction involved in infection-induced disease activity of lupus? 2) What are the risks of CpG motifs in vaccine adjuvants for lupus patients? 3) Is TLR9 signalling involved in the pathogenesis of lupus by recognizing self DNA?.

引用

页码：417 / 422

页数：6

共 45 条

[1] Toll-like receptor signalling
Akira, S
Takeda, K
[J]. NATURE REVIEWS IMMUNOLOGY, 2004, 4 (07) : 499 - 511
[2] Activation of toll-like receptor-9 induces progression of renal disease in MRL-Fas(lpr) mice
Anders, HJ
Vielhauer, V
Eis, V
Linde, Y
Kretzler, M
de Lema, GP
Strutz, F
Bauer, S
Rutz, M
Wagner, H
Gröne, HJ
Schlbndorff, D
[J]. FASEB JOURNAL, 2004, 18 (01) : 534 - +
[3] Bacterial CpG-DNA aggravates immune complex glomerulonephritis:: Role of TLR9-mediated expression of chemokines and chemokine receptors
Anders, HJ
Banas, B
Linde, Y
Weller, L
Cohen, CD
Kretzler, M
Martin, S
Vielhauer, V
Schlöndorff, D
Gröne, HJ
[J]. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2003, 14 (02): : 317 - 326
[4] CPG ISLANDS AS GENE MARKERS IN THE VERTEBRATE NUCLEUS
BIRD, AP
[J]. TRENDS IN GENETICS, 1987, 3 (12) : 342 - 347
[5] CPG-RICH ISLANDS AND THE FUNCTION OF DNA METHYLATION
BIRD, AP
[J]. NATURE, 1986, 321 (6067) : 209 - 213
[6] Toll-like receptor 9-dependent and -independent dendritic cell activation by chromatin-immunoglobulin G complexes
Boulé, MW
Broughton, C
Mackay, F
Akira, S
Marshak-Rothstein, A
Rifkin, IR
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2004, 199 (12) : 1631 - 1640
[7] Shaping the nuclear action of NF-κB
Chen, LF
Greene, WC
[J]. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2004, 5 (05) : 392 - 401
[8] Safety and immunogenicity of CPG 7909 injection as an adjuvant to Fluarix influenza vaccine
Cooper, CL
Davis, HL
Morris, ML
Efler, SM
Krieg, AM
Li, Y
Laframboise, C
Al Adhami, MJ
Khaliq, Y
Seguin, I
Cameron, DW
[J]. VACCINE, 2004, 22 (23-24) : 3136 - 3143
[9] Direct evidence that toll-like receptor 9 (TLR9) functionally binds plasmid DNA by specific cytosine-phosphate-guanine motif recognition
Cornélie, S
Hoebeke, J
Schacht, AM
Bertin, B
Vicogne, J
Capron, M
Riveau, G
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (15) : 15124 - 15129
[10] A phase I study of the safety and immunogenicity of recombinant hepatitis B surface antigen co-administered with an immunostimulatory phosphorothioate oligonucleotide adjuvant
Halperin, SA
Van Nest, G
Smith, B
Abtahi, S
Whiley, H
Eiden, JJ
[J]. VACCINE, 2003, 21 (19-20) : 2461 - 2467

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