HLA allele distribution distinguishes sporadic inclusion body myositis from hereditary inclusion body myopathies

被引：52

作者：

Koffman, BM ^{[1
]}

Sivakumar, K ^{[1
]}

Simonis, T ^{[1
]}

Stroncek, D ^{[1
]}

Dalakas, MC ^{[1
]}

机构：

[1] Neuromuscular Dis Sect, Bethesda, MD 20892 USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 1998年 / 84卷 / 02期

关键词：

inclusion body myositis; HLA association; immunogenetics;

D O I：

10.1016/S0165-5728(97)00245-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We studied the HLA class II associations in patients with sporadic inclusion body myositis (s-IBM) and hereditary inclusion body myopathies (h-IBM) and attempted to distinguish these myopathies on the basis of HLA allele assignments. Forty-five patients, 30 with s-IBM and 15 with h-IBM, underwent HLA class II allele-specific typing using polymerase chain reaction sequence-specific primers for 71 alleles contained in the DR beta 1, DR beta 3-5, and DQ beta 1 loci. In s-IBM, we found a high (up to 77%) frequency of DR beta 1*0301, DR beta 3*0101 (or DR beta 3*0202) and DQ beta 1*0201 alleles. No significant association with alleles in the DR and De haplotypes was found among the 15 h-IBM patients. The strong association of prominent alleles with s-IBM, but not h-IBM, suggests that s-IBM is a distinct disorder with an immunogenetic background that differs from h-IBM. Published by Elsevier Science B.V.

引用

页码：139 / 142

页数：4

共 27 条

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