Preparative purification of the major anti-inflammatory triterpenoid esters from marigold (Calendula officinalis)

被引：92

作者：

Hamburger, M

Adler, S

Baumann, D

Förg, A

Weinreich, B

机构：

[1] Univ Jena, Inst Pharm, D-07743 Jena, Germany

[2] Adalbert Raps Zentrum Arznell & Gewurzpflanzenfor, D-85350 Freising Weihenstephan, Germany

来源：

FITOTERAPIA | 2003年 / 74卷 / 04期

关键词：

Calendula officinalis; supercritical fluid extraction; faradiol; low-pressure liquid chromatography; preparative HPLC;

D O I：

10.1016/S0367-326X(03)00051-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A method for the efficient preparative purification of faradiol. 3-O-laurate, palmitate, and myristate, the major anti-inflammatory triterpenoid esters in the flower heads of the medicinal plant Calendula officinalis has been developed. Gram quantities of the individual compounds were obtained with 96 to 98% purity by a combination of supercritical. fluid extraction (SFE), normal-phase and reversed-phase column chromatography. During the work-up of the faradiol esters, accompanying minor compounds of the triterpene ester fraction were purified and identified by spectroscopic means as maniladiol 3-O-laurate and myristate. (C) 2003 Elsevier Science B.V. All rights reserved.

引用

页码：328 / 338

页数：11

共 20 条

[1] Triterpene alcohols from the flowers of compositae and their anti-inflammatory effects [J].