Association of apolipoprotein E polymorphism to clinical heterogeneity of multiple sclerosis

被引：36

作者：

Ballerini, C

Campani, D

Rambolà, G

Gran, B

Nacmias, B

Amato, MP

Siracusa, G

Bartolozzi, L

Sorbi, S

Massacesi, L

机构：

[1] Univ Florence, Dept Neurol & Psychiat Sci, I-50134 Florence, Italy

[2] Careggi Univ Hosp, Serv Immunogenet, I-50134 Florence, Italy

来源：

NEUROSCIENCE LETTERS | 2000年 / 296卷 / 2-3期

关键词：

apolipoprotein E; multiple sclerosis; disease heterogeneity;

D O I：

10.1016/S0304-3940(00)01646-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In this study we investigated the distribution of apolipoprotein E (APO E) genotypes in sporadic multiple sclerosis (MS) cases and in normal controls. Later onset of chronic progressive MS was observed in patients carrying the epsilon2 allele, whereas APO E alleles were found at similar frequency in MS and in the control population. These findings indicate that clinical heterogeneity, but probably not susceptibility to the disease, is associated to APO E genotypes. (C) 2000 Published by Elsevier Science Ireland Ltd.

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收藏

页码：174 / 176

页数：3

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