The human transcriptome map:: Clustering of highly expressed genes in chromosomal domains

被引：569

作者：

Caron, H

van Schaik, B

van der Mee, M

Baas, F

Riggins, G

van Sluis, P

Hermus, MC

van Asperen, R

Boon, K

Voûte, PA

Heisterkamp, S

van Kampen, A

Versteeg, R

机构：

[1] Emma Childrens Hosp, Acad Med Ctr, Dept Human Genet, NL-1100 DE Amsterdam, Netherlands

[2] Emma Childrens Hosp, Acad Med Ctr, Dept Pediat Oncol, NL-1100 DE Amsterdam, Netherlands

[3] Univ Amsterdam, Acad Med Ctr, Bioinformat Lab, NL-1105 AZ Amsterdam, Netherlands

[4] Univ Amsterdam, Acad Med Ctr, Neurozintuigen Lab, NL-1105 AZ Amsterdam, Netherlands

[5] Univ Amsterdam, Acad Med Ctr, Dept Clin Epidemiol & Biostat, NL-1105 AZ Amsterdam, Netherlands

[6] Duke Univ, Med Ctr, Dept Genet, Durham, NC 27710 USA

[7] Duke Univ, Med Ctr, Dept Pathol, Durham, NC 27710 USA

来源：

SCIENCE | 2001年 / 291卷 / 5507期

关键词：

D O I：

10.1126/science.1056794

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The chromosomal position of human genes is rapidly being established. We integrated these mapping data with genome-wide messenger RNA expression profiles as provided by SAGE (serial analysis of gene expression). Over 2.45 million SAGE transcript tags, including 160,000 tags of neuroblastomas, are presently known for 12 tissue types. We developed algorithms to assign these tags to UniGene clusters and their chromosomal position. The resulting Human Transcriptome Map generates gene expression profiles for ant chromosomal region in 12 normal and pathologic tissue types. The map reveals a clustering of highly expressed genes to specific chromosomal regions. It provides a tool to search for genes that are overexpressed or silenced in cancer.

引用

页码：1289 / +

页数：5

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