Host genetic resistance to symptomatic norovirus (GGII.4) infections in Denmark

被引：57

作者：

Kindberg, Elin

Akerlind, Britt

Johnsen, Christina

Knudsen, Jenny Dahl

Heltberg, Ole

Larson, Goeran

Boettiger, Blenda

Svensson, Lennart ^{[1
]}

机构：

[1] Linkoping Univ, Fac Med, Div Mol Virol, S-58185 Linkoping, Sweden

[2] Natl Board Forens Med, Dept Forens Genet, Linkoping, Sweden

[3] Linkoping Univ Hosp, Div Clin Microbiol, S-58185 Linkoping, Sweden

[4] Statens Serum Inst, Dept Virol, DK-2300 Copenhagen, Denmark

[5] Hvidovre Univ Hosp, Dept Microbiol, Hvidovre, Denmark

[6] Naestved Hosp, Dept Microbiol, Naestved, Denmark

[7] Sahlgrens Univ Hosp, Dept Clin Chem & Transfusion Med, S-41345 Gothenburg, Sweden

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2007年 / 45卷 / 08期

关键词：

D O I：

10.1128/JCM.00162-07

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A total of 61 individuals involved in five norovirus outbreaks in Denmark were genotyped at nucleotides 428 and 571 of the FUT2 gene, determining secretor status, i.e., the presence of ABH antigens in secretions and on mucosa. A strong correlation (P = 0.003) was found between the secretor phenotype and symptomatic disease, extending previous knowledge and confirming that nonsense mutations in the FUT2 gene provide protection against symptomatic norovirus (GGII.4) infections.

引用

页码：2720 / 2722

页数：3

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