Impact of methadone treatment on cardiac repolarization and conduction in opioid users

被引：132

作者：

Martell, BA

Arnsten, JH

Krantz, MJ

Gourevitch, MN

机构：

[1] VA Connecticut Healthcare Cooperat Studies Progra, West Haven, CT 06516 USA

[2] Yale Univ, Sch Med, Gen Internal Med Sect, New Haven, CT USA

[3] Montefiore Med Ctr, Dept Psychiat & Behav Sci, Div Subst Abuse, Bronx, NY 10467 USA

[4] Montefiore Med Ctr, Dept Epidemiol & Populat Hlth, AIDS Res Program, Bronx, NY 10467 USA

[5] Montefiore Med Ctr, Dept Med, Bronx, NY 10467 USA

[6] Albert Einstein Coll Med, Bronx, NY 10467 USA

[7] Denver Hlth Med Ctr, Div Cardiol, Denver, CO USA

[8] Univ Colorado, Hlth Sci Ctr, Denver, CO 80262 USA

[9] NYU, Sch Med, Dept Med, Div Gen Internal Med, New York, NY USA

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 2005年 / 95卷 / 07期

关键词：

D O I：

10.1016/j.amjcard.2004.11.055

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We prospective assessed the effect of oral methadone on the corrected QT interval (QTc) among 160 patients free of structural heart disease and measured serum methadone concentrations and simultaneous QTc intervals in a subset of 44 participants. Mean +/- SD QTc increased by 12.4 +/- 23 ms (p < 0.001) at 6 months, by 10.7 +/- 30 ms (p < 0.001) at 12 months, and the QTc change from baseline to 12 months correlated with the trough (r = 0.37, p = 0.008) and peak (r = 0.32, p = 0.03) serum methadone concentrations. (c) 2005 by Excerpta Medical Inc.

引用

页码：915 / 918

页数：4

共 7 条

[1] What clinicians should know about the QT interval [J].

Al-Khatib, SM ;

LaPointe, NMA ;

Kramer, JM ;

Califf, RM .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2003, 289 (16) :2120-2127

[2] Increase in deaths due to methadone in North Carolina [J].

Ballesteros, MF ;

Budnitz, DS ;

Sanford, CP ;

Gilchrist, J ;

Agyekum, GA ;

Butts, J .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2003, 290 (01) :40-40

[3]

Bazett HC, 1920, HEART-J STUD CIRC, V7, P353

[4]

Gagajewski A, 2003, J FORENSIC SCI, V48, P668

[5]

Gourevitch MN, 2000, MT SINAI J MED, V67, P429

[6] Torsade de Pointes associated with very-high-dose methadone [J].

Krantz, MJ ;

Lewkowiez, L ;

Hays, H ;

Woodroffe, MA ;

Robertson, AD ;

Mehler, PS .

ANNALS OF INTERNAL MEDICINE, 2002, 137 (06) :501-504

[7] The impact of methadone induction on cardiac conduction in opiate users [J].

Martell, BA ;

Arnsten, JH ;

Ray, B ;

Gourevitch, MN .

ANNALS OF INTERNAL MEDICINE, 2003, 139 (02) :154-155

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