New entry to a three-component pyrimidine synthesis by TMS-ynones via Sonogashira coupling

被引：217

作者：

Karpov, AS ^{[1
]}

Muller, TJJ ^{[1
]}

机构：

[1] Univ Heidelberg, Inst Organ Chem, D-69120 Heidelberg, Germany

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 19期

关键词：

D O I：

10.1021/ol035212q

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

TMS-ynones are versatile synthetic equivalents of beta-keto aldehydes and can be readily synthesized in an atom-economical fashion by coupling (het)aroyl chlorides and (TMS)-acetylene with only one equiv (!) of triethylamine under Sonogashira conditions. This mild ynone synthesis is also a suitable entry to 2,4-disubstituted pyrimidines in the sense of a one-pot three-component reaction, i.e., a coupling-addition-cyclocondensation sequence.

引用

页码：3451 / 3454

页数：4

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