Chromatin in need of a fix: Phosphorylation of H2AX connects chromatin to DNA repair

被引：177

作者：

Thiriet, C ^{[1
]}

Hayes, JJ ^{[1
]}

机构：

[1] Univ Rochester, Med Ctr, Dept Biochem & Biophys, Rochester, NY 14642 USA

来源：

MOLECULAR CELL | 2005年 / 18卷 / 06期

关键词：

D O I：

10.1016/j.molcel.2005.05.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A bevy of recent reports have firmly established a mechanistic link between a histone posttranslational modification associated with DNA double-strand breaks and recruitment of chromatin-modifying activities. These papers show that in addition to providing signals for transcriptional regulation, specific histone "codes" can coordinate and target multiple activities involved in DNA repair.

引用

页码：617 / 622

页数：6

共 19 条

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