Adult human hematopoietic cells provide functional hemangioblast activity

被引：61

作者：

Cogle, CR ^{[1
]}

Wainman, DA ^{[1
]}

Jorgensen, ML ^{[1
]}

Guthrie, SM ^{[1
]}

Mames, RN ^{[1
]}

Scott, EW ^{[1
]}

机构：

[1] Univ Florida, Shands Canc Ctr, Program Stem Cell Biol & Regenerat Med, Gainesville, FL 32610 USA

来源：

BLOOD | 2004年 / 103卷 / 01期

关键词：

D O I：

10.1182/blood-2003-06-2101

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The murine adult hematopoietic stem cell is able to function as a hemangioblast, contributing both to blood reconstitution and to blood vessel repair in response to ischemic injury. We developed a novel mouse xenotransplantation model of retinal neovascularization to test human hematopoietic cell plasticity. Immunocompromised nonobese diabetic (NOD)/scid mice underwent myeloablative conditioning and transplantation with human CD34(+) umbilical cord blood. After multilineage reconstitution was established, retinal ischemia was induced to promote neovascularization. Our results demonstrate human retinal neovascularization, thus revealing the functional hemangioblast activity of human hematopoietic cells.

引用

页码：133 / 135

页数：3

共 13 条

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