Swelling characteristics and biocompatibility of ionic liquid based hydrogels for biomedical applications

被引：47

作者：

Claus, Johanna ^{[1
,2
]}

Brietzke, Andreas ^{[3
]}

Lehnert, Celina ^{[1
,2
]}

Oschatz, Stefan ^{[3
]}

Grabow, Niels ^{[2
,3
]}

Kragl, Udo ^{[1
,2
]}

机构：

[1] Univ Rostock, Dept Chem Ind & Appl Chem, Rostock, Germany

[2] Univ Rostock, Dept Life Light & Matter, Rostock, Germany

[3] Rostock Univ, Med Ctr, Inst Biomed Engn, Rostock, Germany

来源：

PLOS ONE | 2020年 / 15卷 / 04期

关键词：

NANOPARTICLES; DEGRADATION;

D O I：

10.1371/journal.pone.0231421

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Polymers are commonly used in medical device manufacturing, e.g. for drug delivery systems, bone substitutes and stent coatings. Especially hydrogels exhibit very promising properties in this field. Hence, the development of new hydrogel systems for customized application is of great interest, especially regarding the swelling behavior and mechanical properties as well as the biocompatibility. The aim of this work was the preparation and investigation of various polyelectrolyte and poly-ionic liquid based hydrogels accessible by radical polymerization. The obtained polymers were covalently crosslinked with N,N'-methylenebisacrylamide (MBAA) or different lengths of poly(ethyleneglycol)diacrylate (PEGDA). The effect of different crosslinker-to-monomer ratios has been examined. In addition to the compression curves and the maximum degree of swelling, the biocompatibility with L929 mouse fibroblasts of these materials was determined in direct cell seeding experiments and the outcome for the different hydrogels was compared.

引用

页数：16

共 46 条

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REORGANIZATION OF SUBSTRATUM-BOUND FIBRONECTIN ON HYDROPHILIC AND HYDROPHOBIC MATERIALS IS RELATED TO BIOCOMPATIBILITY [J].