Downregulation of metallothionein-IIA expression occurs at immortalization

被引：24

作者：

Duncan, EL ^{[1
]}

Reddel, RR ^{[1
]}

机构：

[1] Childrens Med Res Inst, Sydney, NSW 2145, Australia

来源：

ONCOGENE | 1999年 / 18卷 / 04期

关键词：

metallothionein-IIA; immortalization; senescence; SV40;

D O I：

10.1038/sj.onc.1202370

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Metallothioneins (MTs) may modulate a variety of cellular processes by regulating the activity of zinc-binding proteins, These proteins have been implicated in cell growth regulation, and their expression is abnormal in some tumors. In particular, MT-IIA is expressed 27-fold less in human colorectal tumors and tumor cell lines compared with normal tissue (Zhang et al,, 1997), Here we demonstrate that MT-IIA downregulation occurs when human cells become immortal, a key event in tumorigenesis, After immortalization MT-IIA expression remains inducible but the basal activity of the MT-IIA promoter is decreased, MT-IIA downregulation at immortalization is one of the most common immortalization-related changes identified to date, suggesting that MT-IIA has a role in this process.

引用

页码：897 / 903

页数：7

共 42 条

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