Mammaglobin is found in breast tissue as a complex with BU101

被引：39

作者：

Colpitts, TL ^{[1
]}

Billing-Medel, P

Friedman, P

Granados, EN

Hayden, M

Hodges, S

Menhart, N

Roberts, L

Russell, J

Stroupe, SD

机构：

[1] Abbott Labs, Abbott Diagnost Div, Abbott Pk, IL 60064 USA

[2] IIT, Dept Biol Chem & Phys Sci, Chicago, IL 60616 USA

来源：

BIOCHEMISTRY | 2001年 / 40卷 / 37期

关键词：

D O I：

10.1021/bi010284f

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The mammaglobin gene has been shown to be preferentially expressed in breast tissue. Few genes match its specificity. Mammaglobin has generated much interest, and studies are ongoing to develop diagnostic tests for breast cancer based on the detection of mammaglobin. While searching the Incyte Genomics Lifeseq database for tissue-specific markers, we observed a second secretoglobin, BU101, also known as lipophilin B. We report here that mammaglobin, in breast tissue, is found as a complex with BU101. The complex was isolated from breast cancer tissue and was characterized as the biologically relevant form of mammaglobin.

引用

页码：11048 / 11059

页数：12

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