Oxymatrine ameliorates renal ischemia-reperfusion injury from oxidative stress through Nrf2/HO-1 pathway

被引：72

作者：

Jiang, Guanjun ^{[1
]}

Liu, Xiuheng ^{[1
]}

Wang, Min ^{[1
]}

Chen, Hui ^{[1
]}

Chen, Zhiyuan ^{[1
]}

Qiu, Tao ^{[1
]}

机构：

[1] Wuhan Univ, Renmin Hosp, Dept Urol, Wuhan 430060, Hubei Province, Peoples R China

来源：

ACTA CIRURGICA BRASILEIRA | 2015年 / 30卷 / 06期

关键词：

Ischemia; Reperfusion Injury; Oxidative Stress; Kidney; Rats; NRF2-KEAP1; PATHWAY; ISCHEMIA/REPERFUSION; ATTENUATION; MECHANISMS; NRF2;

D O I：

10.1590/S0102-865020150060000008

中图分类号：

R61 [外科手术学];

学科分类号：

100210 [外科学];

摘要：

PURPOSE: To investigate if oxymatrine pretreatment could ameliorate renal I/R injury induced in rats and explore the possible role of oxymatrine in Nrf2/HO-1 pathway. METHODS: Unilaterally nephrectomized rats were insulted by I/R in their left kidney. Twenty four rats were randomly divided into three groups: sham group, I/R + saline-treated group, I/R + OMT-treated group. Oxymatrine or vehicle solution was administered intraperitoneally injected 60 min before renal ischemia, respectively. Renal function, histology, makers of oxidative stress, cell apoptosis and Nrf2/HO-1 expressions were assessed. RESULTS: Oxymatrine pretreatment exhibited an improved renal functional recovery, alleviated histological injury and oxidative stress, inhibiting tubular apoptosis, and accompanied by upregulated the expression of Nrf2/HO-1 proteins. CONCLUSION: Oxymatrine may attenuate renal ischemia/reperfusion injury, and this renoprotective effect may be through activating the Nrf2/HO-1 pathway.

引用

页码：422 / 429

页数：8

共 26 条

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