Polycystins: inhibiting the inhibitors

被引：8

作者：

Benezra, R ^{[1
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA

来源：

NATURE CELL BIOLOGY | 2005年 / 7卷 / 12期

关键词：

D O I：

10.1038/ncb1205-1164

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Polycystin-1 and -2 - two integral membrane proteins that are mutated in polycystic kidney disease - regulate the cell cycle by preventing nuclear localization of the pro-proliferative helix-loop-helix (HLH) protein ld2. This novel mechanism for restraining Id proteins has important implications for our understanding of the nature of polycystic kidney disease and perhaps other proliferative disorders.

引用

页码：1164 / 1165

页数：2

共 16 条

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